high purity Lincomycin HCL 859-18-7 factory in china CAS NO.859-18-7

high purity Lincomycin HCL 859-18-7 factory in china

Lincomycin hydrochloride Basic information

Antibiotic medicines Clinical application

Product Name: Lincomycin hydrochloride

Synonyms: METHYL 6,8-DIDEOXY-6-(1-METHYL-4-PROPYL-2-PYRROLIDINECARBOXAMIDO)-1-THIO-D-ERYTHRO-ALPHA-D-GALACTOOCTOPYRANOSIDE HYDROCHLORIDE;LINCOMYCIN HCL;LINCOMYCIN HYDROCHLORIDE;LINCOCIN HYDROCHLORIDE;ALPHA-METHYL-6,8-DIDEOXY-6-[1-METHYL-4-PROPYL-2-PYRROLIDINECARBOXAMIDO]-1-THIO-D-ERYTHRO-D-GALACTOOCTOPYRANOSIDE HYDROCHLORIDE;U-10149A;N-[2-HYDROXY-1-(3,4,5-TRIHYDROXY-6-METHYLSULFANYL-OXAN-2-YL)-PROPYL]-1-METHYL-4-PROPYL-PYRROLIDINE-2-CARBOXAMIDE;lincomycin standard solution

CAS: 859-18-7

MF: C18H35ClN2O6S

MW: 443

EINECS: 212-726-7

Product Categories: Antibiotic Explorer;Peptide Synthesis/Antibiotics;Carbohydrates & Derivatives;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Lincocin;antibiotic;API

Mol File: 859-18-7.mol

Lincomycin hydrochloride Structure

Lincomycin hydrochloride Chemical Properties

Melting point  156-158C

storage temp.  2-8°C

solubility  H2O: 50 mg/mL, clear, colorless

color  white to white with yellow cast

Water Solubility  Soluble in water.

InChIKey POUMFISTNHIPTI-BOMBIWCESA-N

Safety Information

Hazard Codes	Xi,Xn
Risk Statements	36/37/38-20/21/22
Safety Statements	26-36
WGK Germany	2
RTECS	RH6315000
F	10
HS Code	29419000

MSDS Information

Lincomycin hydrochloride Usage And Synthesis

Antibiotic medicines

Lincomycin hydrochloride appears as a white crystalline powder at room temperature with slight odor or special smell and bitter taste. It is soluble in water and methanol. Feed often applied its hydrochloride salt form. The drug is the product during the growth of the population of the Streptomyces genus (Streptomyces lincolnensis), as a kind of lincosamides alkaline antibiotics. Through interaction with the 50S ribosomal subunit of the sensitive bacteria, it prevents the peptide chain elongation, thereby inhibiting protein synthesis of the bacterial cell with antimicrobial effect. However, at high concentrations, it also has bactericidal effect on the highly sensitive bacteria. Its antibacterial spectrum is the same as lincomycin but with a stronger antibacterial activity and can be subject to oral absorption quickly and completely (about 90%) with meal having little effect on the absorption. Lincomycin hydrochloride mainly has strong antibacterial effect against Gram-positive bacteria, and some anaerobic bacteria as well as Mycoplasma with its antibacterial spectrum narrower than erythromycin. Staphylococcus aureus, Streptococcus pneumoniae and Mycoplasma pneumonia Mycoplasma hyopneumoniae, and Mycoplasma gallisepticum are sensitive to the chemicals, but enterococci is generally resistant to the chemicals; anaerobic bacteria such as Bacteroides spp., Clostridium tetani, Clostridium difficile, Clostridium perfringens and Peptococcus are also sensitive to the chemicals. It is mainly used for the treatment of infections caused by Gram-positive bacteria in particular the various penicillin-resistant Gram-positive bacteria , the poultry chronic respiratory disease caused by Mycoplasma, swine enzootic pneumonia, anaerobic infections such as chicken necrotizing enterocolitis. It can also be used for the treatment of treponema dysentery, toxoplasmosis and actinomycosis of dogs and cats.