D-Threonine Usage And Synthesis
Description D-threonine is the D-form of threonine, which is a kind of amino acids. It can be used for the preparation of enantiomerically pure 1, 3-butanediol. It is also used as the intermediate during the preparation of chiral compounds such as antibiotics. D-threonine is an effective chiral pool reagent which contains an extra stereo-center. For example, people has recently used it as the starting material for total synthesis of protected legionaminic acid.
Chemical Properties white crystalline powder or crystals
Uses A steroisomer of the proteinogenic amino acid L-threonine.
Definition ChEBI: An optically active form of threonine having D-configuration.
References #
Ikemi, Masahisa, et al. "D-Threonine Aldolase and Its Application to D -β-Hydroxy-£-Amino Acid Synthesis." (1992).
Paek SM, et al. "Recent Advances in Substrate-Controlled Asymmetric Induction Derived from Chiral Pool α-Amino Acids for Natural Product Synthesis." Molecules 21.7(2016):951.
D-Threonine Preparation Products And Raw materials
Raw materials Chloroacetyl chloride-->DL-Threonine-->AMINOACYLASE
Preparation Products (2S,3S)-2-Amino-3-methylpentanoic acid-->Cefbuperazone